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Epithelial ovarian cancer (EOC) is an aggressive malignancy and is most regularly diagnosed at an advanced illness stage (1). Currently, essentially the most typical treatment is surgery combined with platinum-based mixture chemotherapy (two). Having said that, 60 of sufferers relapsed just after first-line therapy (three), and 50 showed resistance to chemotherapy. It truly is normally believed that EOC chemotherapy resistance is involved in the DNA damage response (DDR) method with the cell cycle (four, five), in distinct single-strand DNA break repair by poly ADP-ribose polymerase (PARP) and doublestranded repair through homologous recombination repair (HRR) on the BRCA1/2 genes. As a result, it is the crucial to discovering drugs that influence the mechanism of drug resistance. Currently, for the remedy of ovarian cancer, agents that target specific stages of the cell cycle, like cyclin-dependent kinase inhibitors (CDKIs), have shown fantastic efficacy in clinical trials. One example is, ribociclib (six), a CDK4/6 inhibitor, which acts on the G1 phase of your cell cycle has been approved by the US Food and Drug Administration (FDA) for the remedy of breast cancer; it has also been utilised to treat ovarian cancer in phase II clinical trials (NCT02657928). Additionally, AZD5438 (7, eight), a CDK1/2 inhibitor, enhances radiosensitivity of nonsmall cell lung cancer by impairing HRR of double-stranded breaks (DSBs) and has currently been tested in the preclinical stage. Hence, it has been recommended that targeting the cell cycle is often a novel and effective method to treat tumors. Even so, only a handful of CDKIs have so far been deve
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