. Chem. Soc. 2009, 131, 160146015. Ludwig, C.; Marin-Montesinos, I.; Saunders, M.G.; Emwas, A.

. Chem. Soc. 2009, 131, 160146015. Ludwig, C.; Marin-Montesinos, I.; Saunders, M.G.; Emwas, A.H.; Pikramenou, Z.; Hammond, S.P.; Gnther, U.L. Application of ex situ dynamic nuclear polarization in studying modest molecules. Phys. Chem. Chem. Phys. 2010, 12, 5868871. Theis, T.; Feng, Y.; Wu, T.-L.; Warren, W.S. Spin lock composite and shaped pulses for efficient and robust pumping of dark states in magnetic resonance. 2013, arXiv:1308.5666. arXiv.org e-Print archive. Readily available on line: http://arxiv.org/ftp/arxiv/papers/1308/1308.5666.pdf (accessed on 16 Juanuary 2014). Levitt, M.H. Singlet nuclear magnetic resonance. Annu. Rev. Phys. Chem. 2012, 63, 8905. Hurd, R.E.; Yen, Y.F.; Mayer, D.; Chen, A.; Wilson, D.; Kohler, S.; Bok, R.; Vigneron, D.; Kurhanewicz, J.; Tropp, J.; et al. Metabolic imaging within the anesthetized rat brain employing hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn. Reson. Med. 2010, 63, 1137143. Zacharias, N.M.; Chan, H.R.; Sailasuta, N.; Ross, B.D.; Bhattacharya, P. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-13C diethyl succinate. J. Am. Chem. Soc. 2012, 134, 93443. Colombo Serra, S.; Karlsson, M.; Giovenzana, G.B.; Cavallotti, C.; Tedoldi, F.; Aime, S. Hyperpolarized 13C-labelled anhydrides as DNP precursors of metabolic MRI agents. Contrast Media Mol. Imaging 2012, 7, 46977. Allouche-Arnon, H.; Lerche, M.H.; Karlsson, M.; Lenkinski, R.E.; Katz-Brull, R. Deuteration of a molecular probe for DNP hyperpolarization–A new strategy and validation for choline chloride. Contrast Media Mol. Imaging 2011, 6, 49906. Meier, S.; Jensen, P.R.; Duus, J. Real-time detection of central carbon metabolism in living escherichia coli and its response to perturbations. FEBS Lett. 2011, 585, 3133138. Xie, X.S.; Yu, J.; Yang, W.Y. Living cells as test tubes. Science 2006, 312, 22830. van Heeswijk, R.B.; Uffmann, K.; Comment, A.; Kurdzesau, F.; Perazzolo, C.; Cudalbu, C.; Jannin, S.; Konter, J.A.; Hautle, P.; van den Brandt, B.; et al. Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents. Magn. Reson. Med. 2009, 61, 1489493. Lippert, A.R.; Keshari, K.R.; Kurhanewicz, J.; Chang, C.J. A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent. J. Am. Chem. Soc. 2011, 133, 3776779. Gallagher, F.A.; Kettunen, M.I.; Hu, D.E.; Jensen, P.R.; Zandt, R.I.; Karlsson, M.; Gisselsson, A.; Nelson, S.K.; Witney, T.H.; Bohndiek, S.E.; et al. Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate can be a marker of cell necrosis and remedy response in tumors. Proc. Natl. Acad. Sci. USA 2009, 106, 198019806. Schilling, F.; Duwel, S.; Kollisch, U.; Durst, M.; Schulte, R.Sotrovimab F.Darunavir ; Glaser, S.PMID:23546012 J.; Haase, A.; Otto, A.M.; Menzel, M.I. Diffusion of hyperpolarized 13C-metabolites in tumor cell spheroids working with real-time NMR spectroscopy. NMR Biomed. 2013, 26, 55768.Sensors 2014, 14 67.68.69.70.71. 72.73.74.75.76.77.78.79.80. 81.Day, S.E.; Kettunen, M.I.; Gallagher, F.A.; Hu, D.E.; Lerche, M.; Wolber, J.; Golman, K.; Ardenkj -Larsen, J.H.; Brindle, K.M. Detecting tumor response to treatment utilizing hyperpolarized 13 C magnetic resonance imaging and spectroscopy. Nat. Med. 2007, 13, 1382387. Lodi, A.; Woods, S.M.; Ronen, S.M. Remedy using the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells. NMR Biomed. 2013, 26, 29906. Venkatesh, H.S.; Chaumeil, M.M.; Ward, C.S.; Haas-Kogan, D.A.; James, C.D.; Ronen.