Product Name :
Retro-2
Description:
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.
CAS:
1201652-50-7
Molecular Weight:
320.41
Formula:
C19H16N2OS
Chemical Name:
2-(5-methylthiophen-2-yl)-3-phenyl-1,2,3,4-tetrahydroquinazolin-4-one
Smiles :
CC1=CC=C(/C=N/C2=CC=CC=C2C(=O)NC2C=CC=CC=2)S1
InChiKey:
QEGJLRIARJEIPG-DEDYPNTBSA-N
InChi :
InChI=1S/C19H16N2OS/c1-14-11-12-16(23-14)13-20-18-10-6-5-9-17(18)19(22)21-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{8-Bromo-cGMP} MedChemExpress|{8-Bromo-cGMP} Neuronal Signaling|{8-Bromo-cGMP} Epigenetics|{8-Bromo-cGMP} Technical Information|{8-Bromo-cGMP} Description|{8-Bromo-cGMP} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.|Product information|CAS Number: 1201652-50-7|Molecular Weight: 320.41|Formula: C19H16N2OS|Chemical Name: 2-(5-methylthiophen-2-yl)-3-phenyl-1,2,3,4-tetrahydroquinazolin-4-one|Smiles: CC1=CC=C(/C=N/C2=CC=CC=C2C(=O)NC2C=CC=CC=2)S1|InChiKey: QEGJLRIARJEIPG-DEDYPNTBSA-N|InChi: InChI=1S/C19H16N2OS/c1-14-11-12-16(23-14)13-20-18-10-6-5-9-17(18)19(22)21-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 31.25 mg/mL (97.53 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Odesivimab} medchemexpress|{Odesivimab} Filovirus|{Odesivimab} Purity & Documentation|{Odesivimab} Description|{Odesivimab} custom synthesis|{Odesivimab} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:23558135 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Retro-2 (1 μM; 1-4 hours) induces autophagy in GFP-LC3-expressing HeLa cells and promoted the dramatic cytoplasmic accumulation of large autophagosomes. Retro-2 (1 μM; 0.5-4 hours) treatment hows an increase over time of the abundance of LC3-II protein in cells. Retro-2 impairs the trafficking between autophagosomes and lysosomes. Retro-2 abolishes autolysosomes formation. Retro-2 (20 μM; pretreatment for 30 min) inhibits HeLa cell intoxication by ricin, Shiga-like toxins 1 (Stx1) and 2 (Stx2). Retro-2 blocked invasion of cells by the intracellular parasite Leishmania, as well as replication of non-enveloped viruses, including polyoma-, papilloma-, and adeno-associated viruses.|In Vivo:|Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge.|Products are for research use only. Not for human use.|
