Product Name :
Thalidomide-PEG3-NH2
Description:
Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
1957236-10-0
Molecular Weight:
405.40
Formula:
C19H23N3O7
Chemical Name:
4-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles :
NCCOCCOCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
SIRFHSCMWOEOOW-UHFFFAOYSA-N
InChi :
InChI=1S/C19H23N3O7/c20-6-7-27-8-9-28-10-11-29-14-3-1-2-12-16(14)19(26)22(18(12)25)13-4-5-15(23)21-17(13)24/h1-3,13H,4-11,20H2,(H,21,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.{{Voriconazole} web|{Voriconazole} Bacterial|{Voriconazole} Biological Activity|{Voriconazole} Data Sheet|{Voriconazole} manufacturer|{Voriconazole} Epigenetic Reader Domain} |Product information|CAS Number: 1957236-10-0|Molecular Weight: 405.40|Formula: C19H23N3O7|Chemical Name: 4-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione|Smiles: NCCOCCOCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: SIRFHSCMWOEOOW-UHFFFAOYSA-N|InChi: InChI=1S/C19H23N3O7/c20-6-7-27-8-9-28-10-11-29-14-3-1-2-12-16(14)19(26)22(18(12)25)13-4-5-15(23)21-17(13)24/h1-3,13H,4-11,20H2,(H,21,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Dantrolene} site|{Dantrolene} Neuronal Signaling|{Dantrolene} Purity & Documentation|{Dantrolene} Data Sheet|{Dantrolene} manufacturer|{Dantrolene} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PMID:33070944 PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-997.Products are for research use only. Not for human use.|Documents||
