Product Name :
MSC2360844
Description:
MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.
CAS:
1305267-37-1
Molecular Weight:
526.58
Formula:
C26H27FN4O5S
Chemical Name:
6-fluoro-1-{4-[(morpholin-4-yl)methyl]phenyl}-3-(morpholine-4-carbonyl)-1H,4H-5λ⁶-thiochromeno[4,3-c]pyrazole-5,5-dione
Smiles :
O=C(C1=NN(C2=CC=C(CN3CCOCC3)C=C2)C2C3=CC=CC(F)=C3S(=O)(=O)CC=21)N1CCOCC1
InChiKey:
NFHSJYKXENYICE-UHFFFAOYSA-N
InChi :
InChI=1S/C26H27FN4O5S/c27-22-3-1-2-20-24-21(17-37(33,34)25(20)22)23(26(32)30-10-14-36-15-11-30)28-31(24)19-6-4-18(5-7-19)16-29-8-12-35-13-9-29/h1-7H,8-17H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.|Product information|CAS Number: 1305267-37-1|Molecular Weight: 526.58|Formula: C26H27FN4O5S|Chemical Name: 6-fluoro-1-{4-[(morpholin-4-yl)methyl]phenyl}-3-(morpholine-4-carbonyl)-1H,4H-5λ⁶-thiochromeno[4,3-c]pyrazole-5,5-dione|Smiles: O=C(C1=NN(C2=CC=C(CN3CCOCC3)C=C2)C2C3=CC=CC(F)=C3S(=O)(=O)CC=21)N1CCOCC1|InChiKey: NFHSJYKXENYICE-UHFFFAOYSA-N|InChi: InChI=1S/C26H27FN4O5S/c27-22-3-1-2-20-24-21(17-37(33,34)25(20)22)23(26(32)30-10-14-36-15-11-30)28-31(24)19-6-4-18(5-7-19)16-29-8-12-35-13-9-29/h1-7H,8-17H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Grapiprant} MedChemExpress|{Grapiprant} GPCR/G Protein|{Grapiprant} Technical Information|{Grapiprant} In Vivo|{Grapiprant} custom synthesis|{Grapiprant} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Pentagastrin} MedChemExpress|{Pentagastrin} Neuronal Signaling|{Pentagastrin} Activator|{Pentagastrin} Protocol|{Pentagastrin} In Vivo|{Pentagastrin} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32900254 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MSC2360844 (0-10 μM; 1 hours) completely abolished BCR-induced pAkt in Ramos B cells in a concentration-dependent manner with IC50 values of 280 nM. MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48 nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells.|In Vivo:|MSC2360844 (6.6-66 mg/kg; daily from week 2 to 10) ameliorates disease manifestations in a murine SLE model.|Products are for research use only. Not for human use.|
