Product Name :
PU 23
Description:
PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine.
CAS:
817635-93-1
Molecular Weight:
425.52
Formula:
C21H19N3O3S2
Chemical Name:
1-benzoyl-3-[4-(benzylsulfamoyl)phenyl]thiourea
Smiles :
O=C(NC(=S)NC1=CC=C(C=C1)S(=O)(=O)NCC1C=CC=CC=1)C1C=CC=CC=1
InChiKey:
RYIRRFWVFHEXTH-UHFFFAOYSA-N
InChi :
InChI=1S/C21H19N3O3S2/c25-20(17-9-5-2-6-10-17)24-21(28)23-18-11-13-19(14-12-18)29(26,27)22-15-16-7-3-1-4-8-16/h1-14,22H,15H2,(H2,23,24,25,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Epcoritamab} MedChemExpress|{Epcoritamab} CD3|{Epcoritamab} Protocol|{Epcoritamab} In Vitro|{Epcoritamab} custom synthesis|{Epcoritamab} Epigenetic Reader Domain}
Additional information:
PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine.|Product information|CAS Number: 817635-93-1|Molecular Weight: 425.52|Formula: C21H19N3O3S2|Chemical Name: 1-benzoyl-3-[4-(benzylsulfamoyl)phenyl]thiourea|Smiles: O=C(NC(=S)NC1=CC=C(C=C1)S(=O)(=O)NCC1C=CC=CC=1)C1C=CC=CC=1|InChiKey: RYIRRFWVFHEXTH-UHFFFAOYSA-N|InChi: InChI=1S/C21H19N3O3S2/c25-20(17-9-5-2-6-10-17)24-21(28)23-18-11-13-19(14-12-18)29(26,27)22-15-16-7-3-1-4-8-16/h1-14,22H,15H2,(H2,23,24,25,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Abemaciclib} medchemexpress|{Abemaciclib} Cell Cycle/DNA Damage|{Abemaciclib} Biological Activity|{Abemaciclib} In Vitro|{Abemaciclib} manufacturer|{Abemaciclib} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:32880241 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. The combination of PU 23 (Cpd23) and 6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 1.84 and 6.06 μM, respectively. Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 h also significantly increases the amount of 6-MP in cells.|Products are for research use only. Not for human use.|
