Product Name :
Kenpaullone
Sequence:
Purity:
≥98% (TLC)
Molecular Weight:
327.2
Solubility :
Soluble in DMSO (>25mg/ml); insoluble in water or ethanol.
Appearance:
Tan solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Description:
Inhibitor of CDK and GSK Potent inhibitor of CDK1/cyclin B (IC50=400nM).{{1006711-90-5} web|{1006711-90-5} Protocol|{1006711-90-5} In stock|{1006711-90-5} manufacturer} Also inhibits CDK2/cyclin A (IC50=680nM) , CDK5 (IC50=850nM) and with much less effect other kinases. More recently, kenpaullone has been found to be a useful GSK-3β inhibitor (IC50=23nM). Induces pluripotency in somatic cells when used in combination with reprogramming factors. Increases neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.{{1332391-04-4} web|{1332391-04-4} Protocol|{1332391-04-4} In Vivo|{1332391-04-4} supplier}
CAS :
142273-20-9
Solubility:
Soluble in DMSO (>25mg/ml); insoluble in water or ethanol.PMID:29262086
Formula:
C16H11BrN2O
Additional Information :
| Alternative Name 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one | Appearance Tan solid. | CAS 142273-20-9 | Couple Target CDK, GSK | Couple Type Inhibitor | Formula C16H11BrN2O | Identity Determined by 1H-NMR. | MW 327.2 | Purity ≥98% (TLC) | Solubility Soluble in DMSO (>25mg/ml); insoluble in water or ethanol. | Unit of Measure (UM) mg
