Product Name :
SLIGRL-NH2 TFA
Description:
SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2).
CAS:
Molecular Weight:
770.84
Formula:
C31H57F3N10O9
Chemical Name:
(S)-2-((S)-2-amino-3-hydroxypropanamido)-N-((2S, 3S)-1-(2-((S)-1-((S)-1-amino-4-methyl-1-oxopentan-2-ylamino)-5-(diaminomethyleneamino)-1-oxopentan-2-ylamino)-2-oxoethylamino)-3-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2, 2, 2-trifluoroacetate
Smiles :
C[C@@H](CC)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(N)=O.OC(=O)C(F)(F)F
InChiKey:
LVEFPJRPZFTZBQ-DBYSMBDASA-N
InChi :
InChI=1S/C29H56N10O7.C2HF3O2/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3;3-2(4,5)1(6)7/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34);(H,6,7)/t17-,18-,19-,20-,21-,23-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fruquintinib} site|{Fruquintinib} Protein Tyrosine Kinase/RTK|{Fruquintinib} Technical Information|{Fruquintinib} References|{Fruquintinib} manufacturer|{Fruquintinib} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2).|Product information|Molecular Weight: 770.84|Formula: C31H57F3N10O9|Chemical Name: (S)-2-((S)-2-amino-3-hydroxypropanamido)-N-((2S, 3S)-1-(2-((S)-1-((S)-1-amino-4-methyl-1-oxopentan-2-ylamino)-5-(diaminomethyleneamino)-1-oxopentan-2-ylamino)-2-oxoethylamino)-3-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2, 2, 2-trifluoroacetate|Smiles: C[C@@H](CC)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(N)=O.{{SLF} MedChemExpress|{SLF} Autophagy|{SLF} Technical Information|{SLF} Purity|{SLF} supplier|{SLF} Epigenetics} OC(=O)C(F)(F)F|InChiKey: LVEFPJRPZFTZBQ-DBYSMBDASA-N|InChi: InChI=1S/C29H56N10O7.PMID:25147652 C2HF3O2/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3;3-2(4,5)1(6)7/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34);(H,6,7)/t17-,18-,19-,20-,21-,23-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)].|Products are for research use only. Not for human use.|
