Product Name :
SRT 1460
Description:
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.
CAS:
925432-73-1
Molecular Weight:
507.60
Formula:
C26H29N5O4S
Chemical Name:
3,4,5-trimethoxy-N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)benzamide
Smiles :
COC1C=C(C=C(OC)C=1OC)C(=O)NC1=CC=CC=C1C1=CN2C(=N1)SC=C2CN1CCNCC1
InChiKey:
SBEWVVLMFLTQFE-UHFFFAOYSA-N
InChi :
InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Belantamab mafodotin} MedChemExpress|{Belantamab mafodotin} Antibody-drug Conjugate/ADC Related|{Belantamab mafodotin} Biological Activity|{Belantamab mafodotin} Data Sheet|{Belantamab mafodotin} custom synthesis|{Belantamab mafodotin} Epigenetic Reader Domain}
Additional information:
SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.{{Isradipine} medchemexpress|{Isradipine} Calcium Channel|{Isradipine} Biological Activity|{Isradipine} References|{Isradipine} custom synthesis|{Isradipine} Epigenetic Reader Domain} 5 value of 2.PMID:23376608 9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.|Product information|CAS Number: 925432-73-1|Molecular Weight: 507.60|Formula: C26H29N5O4S|Chemical Name: 3,4,5-trimethoxy-N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)benzamide|Smiles: COC1C=C(C=C(OC)C=1OC)C(=O)NC1=CC=CC=C1C1=CN2C(=N1)SC=C2CN1CCNCC1|InChiKey: SBEWVVLMFLTQFE-UHFFFAOYSA-N|InChi: InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 10 mg/mL (19.70 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SRT 1460 (2-6 μM; 72 hours) inhibits cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. The IC50s of those cells are: Patu8988t, 1.62±0.13 μM; SU86.86, 2.31±0.23 μM; Panc-1, 0.66 ±0.02 μM; HPDE, 2.39±0.29 μM. SRT 1460 (5 μM; 16 hours) increases expression of the autophagy marker LC3-II.|Products are for research use only. Not for human use.|
