Product Name :
MtTMPK-IN-8
Description:
MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis[1].
CAS:
Molecular Weight:
508.48
Formula:
C24H24N6O7
Chemical Name:
N-({4-[4-(5-methyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)piperidin-1-yl]phenyl}methyl)-3, 5-dinitrobenzamide
Smiles :
CC1=CN(C2CCN(CC2)C2C=CC(CNC(=O)C3C=C(C=C(C=3)[N+]([O-])=O)[N+]([O-])=O)=CC=2)C(=O)NC1=O
InChiKey:
ZDMGZOOCIIYGOI-UHFFFAOYSA-N
InChi :
InChI=1S/C24H24N6O7/c1-15-14-28(24(33)26-22(15)31)19-6-8-27(9-7-19)18-4-2-16(3-5-18)13-25-23(32)17-10-20(29(34)35)12-21(11-17)30(36)37/h2-5,10-12,14,19H,6-9,13H2,1H3,(H,25,32)(H,26,31,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{IPTG} medchemexpress|{IPTG} {Biochemical Assay Reagents}|{IPTG} Technical Information|{IPTG} Purity|{IPTG} manufacturer|{IPTG} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Cy5-DBCO} web|{Cy5-DBCO} {Fluorescent Dye}|{Cy5-DBCO} Purity & Documentation|{Cy5-DBCO} Purity|{Cy5-DBCO} supplier|{Cy5-DBCO} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis[1].|Product information|Molecular Weight: 508.48|Formula: C24H24N6O7|Chemical Name: N-({4-[4-(5-methyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)piperidin-1-yl]phenyl}methyl)-3, 5-dinitrobenzamide|Smiles: CC1=CN(C2CCN(CC2)C2C=CC(CNC(=O)C3C=C(C=C(C=3)[N+]([O-])=O)[N+]([O-])=O)=CC=2)C(=O)NC1=O|InChiKey: ZDMGZOOCIIYGOI-UHFFFAOYSA-N|InChi: InChI=1S/C24H24N6O7/c1-15-14-28(24(33)26-22(15)31)19-6-8-27(9-7-19)18-4-2-16(3-5-18)13-25-23(32)17-10-20(29(34)35)12-21(11-17)30(36)37/h2-5,10-12,14,19H,6-9,13H2,1H3,(H,25,32)(H,26,31,33)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34337881 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:| Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659. Products are for research use only. Not for human use.|
