Product Name :
Eact
Description:
Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity.
CAS:
461000-66-8
Molecular Weight:
428.50
Formula:
C22H24N2O5S
Chemical Name:
3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Smiles :
COCCN(C(=O)C1=CC(OC)=C(OC)C(=C1)OC)C1=NC(=CS1)C1C=CC=CC=1
InChiKey:
ZUXNHFFVQWADJL-UHFFFAOYSA-N
InChi :
InChI=1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity.|Product information|CAS Number: 461000-66-8|Molecular Weight: 428.50|Formula: C22H24N2O5S|Chemical Name: 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-1,3-thiazol-2-yl)benzamide|Smiles: COCCN(C(=O)C1=CC(OC)=C(OC)C(=C1)OC)C1=NC(=CS1)C1C=CC=CC=1|InChiKey: ZUXNHFFVQWADJL-UHFFFAOYSA-N|InChi: InChI=1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (116.{{B-Raf IN 10} site|{B-Raf IN 10} Raf|{B-Raf IN 10} Technical Information|{B-Raf IN 10} Data Sheet|{B-Raf IN 10} manufacturer|{B-Raf IN 10} Autophagy} 69 mM; Need ultrasonic).{{GCN2 modulator-1} web|{GCN2 modulator-1} Cell Cycle/DNA Damage|{GCN2 modulator-1} Purity & Documentation|{GCN2 modulator-1} In Vitro|{GCN2 modulator-1} manufacturer|{GCN2 modulator-1} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25046520 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels.|Products are for research use only. Not for human use.|
