Product Name :
MK-1064
Description:
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.target: 2-SORA In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg.
CAS:
1207253-08-4
Molecular Weight:
461.90
Formula:
C24H20ClN5O3
Chemical Name:
5′-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(pyridin-2-yl)-[3,3′-bipyridine]-5-carboxamide
Smiles :
COC1C=CC(CNC(=O)C2=CC(=CN=C2C2C=CC=CN=2)C2C=NC=C(Cl)C=2)=NC=1OC
InChiKey:
CKTWQGHVNRYNCM-UHFFFAOYSA-N
InChi :
InChI=1S/C24H20ClN5O3/c1-32-21-7-6-18(30-24(21)33-2)14-29-23(31)19-10-16(15-9-17(25)13-26-11-15)12-28-22(19)20-5-3-4-8-27-20/h3-13H,14H2,1-2H3,(H,29,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bliretrigine} medchemexpress|{Bliretrigine} Membrane Transporter/Ion Channel|{Bliretrigine} Technical Information|{Bliretrigine} Purity|{Bliretrigine} manufacturer|{Bliretrigine} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Luciferase} MedChemExpress|{Luciferase} Metabolic Enzyme/Protease|{Luciferase} Technical Information|{Luciferase} Description|{Luciferase} supplier|{Luciferase} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.PMID:23626759 target: 2-SORA In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg.|Product information|CAS Number: 1207253-08-4|Molecular Weight: 461.90|Formula: C24H20ClN5O3|Chemical Name: 5′-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(pyridin-2-yl)-[3,3′-bipyridine]-5-carboxamide|Smiles: COC1C=CC(CNC(=O)C2=CC(=CN=C2C2C=CC=CN=2)C2C=NC=C(Cl)C=2)=NC=1OC|InChiKey: CKTWQGHVNRYNCM-UHFFFAOYSA-N|InChi: InChI=1S/C24H20ClN5O3/c1-32-21-7-6-18(30-24(21)33-2)14-29-23(31)19-10-16(15-9-17(25)13-26-11-15)12-28-22(19)20-5-3-4-8-27-20/h3-13H,14H2,1-2H3,(H,29,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (108.25 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
