Product Name :
PM226
Description:
PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.
CAS:
1949726-13-9
Molecular Weight:
357.49
Formula:
C22H31NO3
Chemical Name:
9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d][1,2]oxazole
Smiles :
COC1=CC(=CC2OC(C)(C)C3C=NOC=3C=21)C(C)(C)CCCCCC
InChiKey:
VFWIRWAAMNBBFG-UHFFFAOYSA-N
InChi :
InChI=1S/C22H31NO3/c1-7-8-9-10-11-21(2,3)15-12-17(24-6)19-18(13-15)25-22(4,5)16-14-23-26-20(16)19/h12-14H,7-11H2,1-6H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SQ109} web|{SQ109} Inhibitor|{SQ109} Epigenetics|{SQ109} Technical Information|{SQ109} In Vivo|{SQ109} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.|Product information|CAS Number: 1949726-13-9|Molecular Weight: 357.49|Formula: C22H31NO3|Chemical Name: 9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d][1,2]oxazole|Smiles: COC1=CC(=CC2OC(C)(C)C3C=NOC=3C=21)C(C)(C)CCCCCC|InChiKey: VFWIRWAAMNBBFG-UHFFFAOYSA-N|InChi: InChI=1S/C22H31NO3/c1-7-8-9-10-11-21(2,3)15-12-17(24-6)19-18(13-15)25-22(4,5)16-14-23-26-20(16)19/h12-14H,7-11H2,1-6H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bromhexine} site|{Bromhexine} Autophagy|{Bromhexine} Technical Information|{Bromhexine} Description|{Bromhexine} custom synthesis|{Bromhexine} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32496945 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM).|In Vivo:|PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate.|Products are for research use only. Not for human use.|
