Product Name :
AZ-3
Description:
AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.
CAS:
2228908-91-4
Molecular Weight:
385.48
Formula:
C20H28FN7
Chemical Name:
N4-[(2R)-butan-2-yl]-N2-{2-fluoro-5-[(1S, 4S)-5-methyl-2, 5-diazabicyclo[2.2.1]heptan-2-yl]pyridin-3-yl}-5-methylpyrimidine-2, 4-diamine
Smiles :
CN1C[C@@H]2C[C@H]1CN2C1=CN=C(F)C(=C1)NC1=NC(N[C@H](C)CC)=C(C)C=N1
InChiKey:
UPSHDXGMMFOWPL-KBMXLJTQSA-N
InChi :
InChI=1S/C20H28FN7/c1-5-13(3)24-19-12(2)8-23-20(26-19)25-17-7-14(9-22-18(17)21)28-11-15-6-16(28)10-27(15)4/h7-9,13,15-16H,5-6,10-11H2,1-4H3,(H2,23,24,25,26)/t13-,15+,16+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Coelenterazine} MedChemExpress|{Coelenterazine} Reactive Oxygen Species|{Coelenterazine} Purity & Documentation|{Coelenterazine} Formula|{Coelenterazine} manufacturer|{Coelenterazine} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.|Product information|CAS Number: 2228908-91-4|Molecular Weight: 385.{{Futibatinib} web|{Futibatinib} Protein Tyrosine Kinase/RTK|{Futibatinib} Protocol|{Futibatinib} Formula|{Futibatinib} manufacturer|{Futibatinib} Cancer} 48|Formula: C20H28FN7|Chemical Name: N4-[(2R)-butan-2-yl]-N2-{2-fluoro-5-[(1S, 4S)-5-methyl-2, 5-diazabicyclo[2.PMID:32896226 2.1]heptan-2-yl]pyridin-3-yl}-5-methylpyrimidine-2, 4-diamine|Smiles: CN1C[C@@H]2C[C@H]1CN2C1=CN=C(F)C(=C1)NC1=NC(N[C@H](C)CC)=C(C)C=N1|InChiKey: UPSHDXGMMFOWPL-KBMXLJTQSA-N|InChi: InChI=1S/C20H28FN7/c1-5-13(3)24-19-12(2)8-23-20(26-19)25-17-7-14(9-22-18(17)21)28-11-15-6-16(28)10-27(15)4/h7-9,13,15-16H,5-6,10-11H2,1-4H3,(H2,23,24,25,26)/t13-,15+,16+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244.Products are for research use only. Not for human use.|
