Product Name :
JAK/HDAC-IN-1
Description:
JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively.
CAS:
2284621-75-4
Molecular Weight:
450.32
Formula:
C19H21Cl2N7O2
Chemical Name:
6-[4-({5-chloro-4-[(4-chlorophenyl)amino]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]-N-hydroxyhexanamide
Smiles :
ONC(=O)CCCCCN1C=C(C=N1)NC1=NC(NC2C=CC(Cl)=CC=2)=C(Cl)C=N1
InChiKey:
MTOQNLGMTJOJOF-UHFFFAOYSA-N
InChi :
InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively.|Product information|CAS Number: 2284621-75-4|Molecular Weight: 450.32|Formula: C19H21Cl2N7O2|Chemical Name: 6-[4-({5-chloro-4-[(4-chlorophenyl)amino]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]-N-hydroxyhexanamide|Smiles: ONC(=O)CCCCCN1C=C(C=N1)NC1=NC(NC2C=CC(Cl)=CC=2)=C(Cl)C=N1|InChiKey: MTOQNLGMTJOJOF-UHFFFAOYSA-N|InChi: InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20.{{BCI} web|{BCI} Phosphatase|{BCI} Technical Information|{BCI} Formula|{BCI} manufacturer|{BCI} Autophagy} 83 mg/mL (46.{{Pimicotinib} site|{Pimicotinib} Protein Tyrosine Kinase/RTK|{Pimicotinib} Purity & Documentation|{Pimicotinib} Data Sheet|{Pimicotinib} supplier|{Pimicotinib} Autophagy} 26 mM; Need ultrasonic).PMID:33297910 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|JAK/HDAC-IN-1 (Compound 8m) exhibits IC50s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively.|Products are for research use only. Not for human use.|
