Product Name :
Rofecoxib (D5)
Description:
Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
CAS:
544684-93-7
Molecular Weight:
319.39
Formula:
C17H14O4S
Chemical Name:
4-(4-methanesulfonylphenyl)-3-[(2,3,4,5,6-²H₅)phenyl]-2,5-dihydrofuran-2-one
Smiles :
[2H]C1=C(C2=C(COC2=O)C2C=CC(=CC=2)S(C)(=O)=O)C([2H])=C([2H])C([2H])=C1[2H]
InChiKey:
RZJQGNCSTQAWON-VIQYUKPQSA-N
InChi :
InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3/i2D,3D,4D,5D,6D
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib.{{Gossypol} MedChemExpress|{Gossypol} Bcl-2 Family|{Gossypol} Biological Activity|{Gossypol} In stock|{Gossypol} supplier|{Gossypol} Autophagy} Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).{{Sibeprenlimab} web|{Sibeprenlimab} Anti-infection|{Sibeprenlimab} Protocol|{Sibeprenlimab} Description|{Sibeprenlimab} custom synthesis|{Sibeprenlimab} Cancer} |Product information|CAS Number: 544684-93-7|Molecular Weight: 319.PMID:33249950 39|Formula: C17H14O4S|Chemical Name: 4-(4-methanesulfonylphenyl)-3-[(2,3,4,5,6-²H₅)phenyl]-2,5-dihydrofuran-2-one|Smiles: [2H]C1=C(C2=C(COC2=O)C2C=CC(=CC=2)S(C)(=O)=O)C([2H])=C([2H])C([2H])=C1[2H]|InChiKey: RZJQGNCSTQAWON-VIQYUKPQSA-N|InChi: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3/i2D,3D,4D,5D,6D|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|
