Product Name :
(R)-JNJ-31020028
Description:
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.
CAS:
1094873-17-2
Molecular Weight:
565.68
Formula:
C34H36FN5O2
Chemical Name:
N-(4-{4-[(R)-(diethylcarbamoyl)(phenyl)methyl]piperazin-1-yl}-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
Smiles :
CCN(CC)C(=O)[C@@H](C1C=CC=CC=1)N1CCN(CC1)C1=CC=C(C=C1F)NC(=O)C1=CC=CC=C1C1=CN=CC=C1
InChiKey:
OVUNRYUVDVWTTE-JGCGQSQUSA-N
InChi :
InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)/t32-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.|Product information|CAS Number: 1094873-17-2|Molecular Weight: 565.{{Riluzole} site|{Riluzole} Sodium Channel|{Riluzole} Technical Information|{Riluzole} In Vivo|{Riluzole} manufacturer|{Riluzole} Cancer} 68|Formula: C34H36FN5O2|Chemical Name: N-(4-{4-[(R)-(diethylcarbamoyl)(phenyl)methyl]piperazin-1-yl}-3-fluorophenyl)-2-(pyridin-3-yl)benzamide|Smiles: CCN(CC)C(=O)[C@@H](C1C=CC=CC=1)N1CCN(CC1)C1=CC=C(C=C1F)NC(=O)C1=CC=CC=C1C1=CN=CC=C1|InChiKey: OVUNRYUVDVWTTE-JGCGQSQUSA-N|InChi: InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)/t32-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{M-CSF Protein, Mouse} site|{M-CSF Protein, Mouse} Purity & Documentation|{M-CSF Protein, Mouse} In Vivo|{M-CSF Protein, Mouse} supplier|{M-CSF Protein, Mouse} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:31549852 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|(R)-JNJ-31020028 (5.6 μg; chronic icv infusion; daily for 10 days) has antidepressant like effects in the olfactory bulbectomized rat (OBX) model. Chronic icv administration of (R)-JNJ-31020028 at 5.6 μg/day using osmotic Alzet pump resulted in a significant decreases number of grooming events. (R)-JNJ-31020028 treatment shows the Cmax, Tmax , AUCinf, Vd, and t1/2 were 4.35 μM, 0.5 hours, 7.91 h μM and 0.83 hours, respectively.|Products are for research use only. Not for human use.|