Product Name :
Nav1.7-IN-3
Description:
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.
CAS:
1788872-06-9
Molecular Weight:
430.95
Formula:
C17H20ClFN4O2S2
Chemical Name:
5-chloro-2-fluoro-4-{[(hexahydro-1H-pyrrolizin-7a-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
Smiles :
O=S(=O)(NC1=NC=CS1)C1=CC(Cl)=C(C=C1F)NCC12CCCN1CCC2
InChiKey:
XFWKBJBSEOZBRA-UHFFFAOYSA-N
InChi :
InChI=1S/C17H20ClFN4O2S2/c18-12-9-15(27(24,25)22-16-20-5-8-26-16)13(19)10-14(12)21-11-17-3-1-6-23(17)7-2-4-17/h5,8-10,21H,1-4,6-7,11H2,(H,20,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Merocyanin 540} MedChemExpress|{Merocyanin 540} {Fluorescent Dye}|{Merocyanin 540} Technical Information|{Merocyanin 540} Formula|{Merocyanin 540} custom synthesis|{Merocyanin 540} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.|Product information|CAS Number: 1788872-06-9|Molecular Weight: 430.95|Formula: C17H20ClFN4O2S2|Chemical Name: 5-chloro-2-fluoro-4-{[(hexahydro-1H-pyrrolizin-7a-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide|Smiles: O=S(=O)(NC1=NC=CS1)C1=CC(Cl)=C(C=C1F)NCC12CCCN1CCC2|InChiKey: XFWKBJBSEOZBRA-UHFFFAOYSA-N|InChi: InChI=1S/C17H20ClFN4O2S2/c18-12-9-15(27(24,25)22-16-20-5-8-26-16)13(19)10-14(12)21-11-17-3-1-6-23(17)7-2-4-17/h5,8-10,21H,1-4,6-7,11H2,(H,20,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33297782 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes).|Products are for research use only. Not for human use.|
