Product Name :
MDA5 (human) monoclonal antibody (Hely-1)
Sequence:
Purity:
Molecular Weight:
Solubility :
Appearance:
Use/Stability :
Description:
MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain.{{137234-62-9} web|{137234-62-9} Purity & Documentation|{137234-62-9} Description|{137234-62-9} manufacturer} After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses.{{1817626-54-2} medchemexpress|{1817626-54-2} Biological Activity|{1817626-54-2} References|{1817626-54-2} supplier}
CAS :
Solubility:
Formula:
Additional Information :
| Alternative Name Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2 | Application ELISA, IP, WB | Application Notes ELISAImmunoprecipitation (1:100)Western Blot (1:1’000) | Clone Hely-1 | Formulation Liquid.PMID:29261963 In PBS containing 10% glycerol and 0.02% sodium azide. | Host Mouse | Immunogen Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555). | Isotype IgG1 | Recommendation Dilutions/Conditions Immunoprecipitation (1:100)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from concentrated hybridoma tissue cell culture supernatant. | Species Reactivity Human | UniProt ID Q9BYX4 | Unit of Measure (UM) µg
