Product Name :
PRIMA-1
Description:
PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
CAS:
5608-24-2
Molecular Weight:
185.22
Formula:
C9H15NO3
Chemical Name:
2, 2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Smiles :
OCC1(CO)C(=O)C2CCN1CC2
InChiKey:
RFBVBRVVOPAAFS-UHFFFAOYSA-N
InChi :
InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.{{Cofetuzumab pelidotin} MedChemExpress|{Cofetuzumab pelidotin} Microtubule/Tubulin|{Cofetuzumab pelidotin} Epigenetics|{Cofetuzumab pelidotin} Protocol|{Cofetuzumab pelidotin} Description|{Cofetuzumab pelidotin} custom synthesis} |Product information|CAS Number: 5608-24-2|Molecular Weight: 185.{{1-(4-Chlorophenyl)piperazine} medchemexpress|{1-(4-Chlorophenyl)piperazine} {Drug Intermediate}|{1-(4-Chlorophenyl)piperazine} Purity & Documentation|{1-(4-Chlorophenyl)piperazine} Formula|{1-(4-Chlorophenyl)piperazine} custom synthesis|{1-(4-Chlorophenyl)piperazine} Cancer} 22|Formula: C9H15NO3|Synonym:|NSC-281668|Chemical Name: 2, 2-bis(hydroxymethyl)-1-azabicyclo[2.PMID:32716640 2.2]octan-3-one|Smiles: OCC1(CO)C(=O)C2CCN1CC2|InChiKey: RFBVBRVVOPAAFS-UHFFFAOYSA-N|InChi: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (269.95 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The cell lines are cultured in the presence of PRIMA-1 (NSC-281668) at 0-140 μM. The IC50s are 35, 40, 50, 50, 60, 70 and 75 μM for PANC-1, HEC-1-B, SUM149, AN 3CA, Ishikawa, Panc02 and MDA-MB-231 cells, respectively.|In Vivo:|PRIMA-1 (Prima-1) is a p53-modulating agent. 150 or 300 ppm PRIMA-1 significantly suppresses (PReferences:|Zhang Z, et al. Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Apr 8.Rao CV, et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia. 2013 Sep;15(9):1018-27. Products are for research use only. Not for human use.|
