Product Name :
SPD304
Description:
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α.
CAS:
869998-49-2
Molecular Weight:
547.61
Formula:
C32H32F3N3O2
Chemical Name:
6, 7-dimethyl-3-[methyl(2-[methyl(1-[3-(trifluoromethyl)phenyl]-1H-indol-3-ylmethyl)amino]ethyl)amino]methyl-4H-chromen-4-one
Smiles :
CC1=CC2OC=C(CN(C)CCN(C)CC3=CN(C4=CC=CC=C34)C3=CC(=CC=C3)C(F)(F)F)C(=O)C=2C=C1C
InChiKey:
JZNXLPPJRFFECJ-UHFFFAOYSA-N
InChi :
InChI=1S/C32H32F3N3O2/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Reproxalap web
Shelf Life:
≥360 days if stored properly.Valsartan Epigenetics
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α.|Product information|CAS Number: 869998-49-2|Molecular Weight: 547.61|Formula: C32H32F3N3O2|Chemical Name: 6, 7-dimethyl-3-[methyl(2-[methyl(1-[3-(trifluoromethyl)phenyl]-1H-indol-3-ylmethyl)amino]ethyl)amino]methyl-4H-chromen-4-one|Smiles: CC1=CC2OC=C(CN(C)CCN(C)CC3=CN(C4=CC=CC=C34)C3=CC(=CC=C3)C(F)(F)F)C(=O)C=2C=C1C|InChiKey: JZNXLPPJRFFECJ-UHFFFAOYSA-N|InChi: InChI=1S/C32H32F3N3O2/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (45.PMID:33103597 65 mM; Need ultrasonic) H2O : 20 mg/mL (36.52 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation.|In Vivo:|SPD304 cannot be used in vivo due to its high toxicity.|References:|Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005.Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805.Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424.Products are for research use only. Not for human use.|
