Product Name :
Protein kinase affinity probe 1
Description:
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3).
CAS:
2098621-90-8
Molecular Weight:
531.09
Formula:
C26H39ClN8O2
Chemical Name:
N-(6-aminohexyl)-2-chloro-4-[(2-[(2R)-1-hydroxy-3-methylbutan-2-yl]amino-9-(propan-2-yl)-9H-purin-6-yl)amino]benzamide
Smiles :
CC(C)N1C=NC2C(NC3C=C(Cl)C(=CC=3)C(=O)NCCCCCCN)=NC(N[C@@H](CO)C(C)C)=NC1=2
InChiKey:
DXPRFXZSNLVXII-NRFANRHFSA-N
InChi :
InChI=1S/C26H39ClN8O2/c1-16(2)21(14-36)32-26-33-23(22-24(34-26)35(15-30-22)17(3)4)31-18-9-10-19(20(27)13-18)25(37)29-12-8-6-5-7-11-28/h9-10,13,15-17,21,36H,5-8,11-12,14,28H2,1-4H3,(H,29,37)(H2,31,32,33,34)/t21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3).|Product information|CAS Number: 2098621-90-8|Molecular Weight: 531.09|Formula: C26H39ClN8O2|Chemical Name: N-(6-aminohexyl)-2-chloro-4-[(2-[(2R)-1-hydroxy-3-methylbutan-2-yl]amino-9-(propan-2-yl)-9H-purin-6-yl)amino]benzamide|Smiles: CC(C)N1C=NC2C(NC3C=C(Cl)C(=CC=3)C(=O)NCCCCCCN)=NC(N[C@@H](CO)C(C)C)=NC1=2|InChiKey: DXPRFXZSNLVXII-NRFANRHFSA-N|InChi: InChI=1S/C26H39ClN8O2/c1-16(2)21(14-36)32-26-33-23(22-24(34-26)35(15-30-22)17(3)4)31-18-9-10-19(20(27)13-18)25(37)29-12-8-6-5-7-11-28/h9-10,13,15-17,21,36H,5-8,11-12,14,28H2,1-4H3,(H,29,37)(H2,31,32,33,34)/t21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ivacaftor Autophagy |Shelf Life: ≥12 months if stored properly.BIBR 1532 In stock |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31870917 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|“S” indicates that the PKI (Purvalanol B) is sepharose-bound. In a series of pull-down experiments from the lysates of HeLa cells, the effects of 0.1, 0.5, 1, 2, 5, 10, 25, and 50% loadings of PK inhibitors is determined. Examine higher bead loadings (75 and 100%) are prevented due to lack of compound solubility and poor reproducibility of the synthesis outcomes. 50% loading is the highest feasible in this study.|References:|Deane FM, et al. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838.Products are for research use only. Not for human use.|
