Product Name :
Nodinitib-1
Description:
Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.
CAS:
799264-47-4
Molecular Weight:
287.34
Formula:
C14H13N3O2S
Chemical Name:
1-(4-methylbenzenesulfonyl)-1H-1,3-benzodiazol-2-amine
Smiles :
CC1C=CC(=CC=1)S(=O)(=O)N1C(N)=NC2=CC=CC=C12
InChiKey:
SRFABRWQVPCPRG-UHFFFAOYSA-N
InChi :
InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.|Product information|CAS Number: 799264-47-4|Molecular Weight: 287.34|Formula: C14H13N3O2S|Chemical Name: 1-(4-methylbenzenesulfonyl)-1H-1,3-benzodiazol-2-amine|Smiles: CC1C=CC(=CC=1)S(=O)(=O)N1C(N)=NC2=CC=CC=C12|InChiKey: SRFABRWQVPCPRG-UHFFFAOYSA-N|InChi: InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 20 mg/mL (69.Nemolizumab Interleukin Related 60 mM; Need ultrasonic and warming).Anti-Spike-RBD mAb custom synthesis |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Nodinitib-1 selectively inhibits IL-8 production induced by NOD1 ligand.PMID:33319617 Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity. Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay.|Products are for research use only. Not for human use.|
