Product Name :
Lys05
Description:
Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
CAS:
1391426-24-6
Molecular Weight:
549.75
Formula:
C23H26Cl5N5
Chemical Name:
7-chloro-N-[2-(2-[(7-chloroquinolin-4-yl)amino]ethyl(methyl)amino)ethyl]quinolin-4-amine trihydrochloride
Smiles :
Cl.Cl.Cl.CN(CCNC1=CC=NC2C=C(Cl)C=CC=21)CCNC1=CC=NC2=CC(Cl)=CC=C12
InChiKey:
JTUYDBHQGOZPQQ-UHFFFAOYSA-N
InChi :
InChI=1S/C23H23Cl2N5.3ClH/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23;;;/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.|Product information|CAS Number: 1391426-24-6|Molecular Weight: 549.75|Formula: C23H26Cl5N5|Chemical Name: 7-chloro-N-[2-(2-[(7-chloroquinolin-4-yl)amino]ethyl(methyl)amino)ethyl]quinolin-4-amine trihydrochloride|Smiles: Cl.Laropiprant Purity & Documentation Cl.Nirsevimab Anti-infection Cl.PMID:32976046 CN(CCNC1=CC=NC2C=C(Cl)C=CC=21)CCNC1=CC=NC2=CC(Cl)=CC=C12|InChiKey: JTUYDBHQGOZPQQ-UHFFFAOYSA-N|InChi: InChI=1S/C23H23Cl2N5.3ClH/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23;;;/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (45.48 mM; ultrasonic and adjust pH to 2 with HCl). H2O : 6.4 mg/mL (11.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Lys01, is a 10-fold more potent autophagy inhibitor than HCQ. Compared with HCQ, Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome. Lys01 and Lys05 produce equivalent dose-dependent increases in the LC3II/LC3I ratio, accumulation of the autophagy cargo protein p62, and identical IC50 values in the MTT assay.|In Vivo:|With this high-dose, short-term treatment, no mice die, but after 2 d of dosing, mice treated with Lys05 76 mg/kg i.p. are observed to have arched backs and lethargy. Morphologically, EM show that cells with intact nuclear and cytoplasmic membranes contain large AVs in Lys05-treated tumors. Tumor growth is significantly impaired in Lys05-treated tumors compared with controls. Lys05 treatment results in a 53% reduction in the average daily tumor growth rate compared with vehicle-treated controls. A significant three- and six-fold accumulation of AV is observed at the end of 14 d of treatment in HCQ- and Lys05-treated tumors, respectively, compared with control-treated tumors.|Products are for research use only. Not for human use.|
