Product Name :
Fradafiban
Description:
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
CAS:
148396-36-5
Molecular Weight:
367.40
Formula:
C20H21N3O4
Chemical Name:
2-[(3S,5S)-5-[(4′-carbamimidoyl-[1,1′-biphenyl]-4-yloxy)methyl]-2-oxopyrrolidin-3-yl]acetic acid
Smiles :
NC(=N)C1C=CC(=CC=1)C1C=CC(=CC=1)OC[C@@H]1C[C@@H](CC(O)=O)C(=O)N1
InChiKey:
IKZACQMAVUIGPY-HOTGVXAUSA-N
InChi :
InChI=1S/C20H21N3O4/c21-19(22)14-3-1-12(2-4-14)13-5-7-17(8-6-13)27-11-16-9-15(10-18(24)25)20(26)23-16/h1-8,15-16H,9-11H2,(H3,21,22)(H,23,26)(H,24,25)/t15-,16-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ataluren Epigenetic Reader Domain
Shelf Life:
≥12 months if stored properly.FGF-8b Protein, Human/Mouse supplier
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.|Product information|CAS Number: 148396-36-5|Molecular Weight: 367.40|Formula: C20H21N3O4|Chemical Name: 2-[(3S,5S)-5-[(4′-carbamimidoyl-[1,1′-biphenyl]-4-yloxy)methyl]-2-oxopyrrolidin-3-yl]acetic acid|Smiles: NC(=N)C1C=CC(=CC=1)C1C=CC(=CC=1)OC[C@@H]1C[C@@H](CC(O)=O)C(=O)N1|InChiKey: IKZACQMAVUIGPY-HOTGVXAUSA-N|InChi: InChI=1S/C20H21N3O4/c21-19(22)14-3-1-12(2-4-14)13-5-7-17(8-6-13)27-11-16-9-15(10-18(24)25)20(26)23-16/h1-8,15-16H,9-11H2,(H3,21,22)(H,23,26)(H,24,25)/t15-,16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32981461 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.|In Vivo:|Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion.|Products are for research use only. Not for human use.|
