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Our benefits demonstrate that intravitreal injection or eye-drop software of the Tat-mCL inhibited photoreceptor mobile death in the early levels of degeneration in S334ter and P23H rats (Figures 2, 3 and 5). In P23H rats, the peptide also prevented nuclear translocation

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Subsequent, we established whether eye-drop programs of Tat-mCL prevented AIF translocation to photoreceptor nuclei...
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CACO-two/TC7 cells possibly unstimulated or stimulated with PT-Gly (1mg/ml), p10-mer (fifty mg/ml), p10mer (50 mg/ml) + PT-Gly (1mg/ml), ended up analyzed by Western blot for ERK and p38 phosphorylation. Phosphorylated ranges of ERK have been analyzed in total cell extracts

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Soon after remedy, cells have been placed on ice, washed after in Phosphate Buffered...